Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. [3], Spinosad is a novel mode-of-action insecticide derived from a family of natural products obtained by fermentation of S. spinosa. Spinosoid binding leads to disruption of acetylcholine neurotransmission. [2] Spinosad is relatively nonpolar and not easily dissolved in water. [6] Spinosyn A resembles a GABA antagonist and is comparable to the effect of avermectin on insect neurons. Techincal Name Trade Name Manfacturer / Distributor General Code for Pesticide Formulation a.i. Toxicity in mammals. [5][clarification needed] [2], Spinosad is sold under the trade names, Comfortis, Trifexis, and Natroba. Spinosad is a metabolite produced by fermentation of the naturally occurring soil bacteria Saccharopolyspora spinosa. Brand names: Natroba. … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [5] Its overall protective effect varies with insect species and life stage. Spinosad(Natroba) generic is a pediculicide (a topical suspension), prescribed for head lice. It works by causing nervous system excitation in insects. Spinosad 0.9% topical suspension is used to treat head lice infestations. Conserve SC Spinosad/spintor Spinosyn A and Spinosyn D 5 Dow AgroSciences Coragen Chlorantraniliprole 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide 28 Dupont Co-Ral Coumaphos O,O-diethyl O-(3-chloro-4-methyl-2-oxo2H-1-enzopyuran 7-yl- phosphorothioate 1B Bayer Corporation These include thrips, leafminers, spider mites, mosquitoes, ants, fruit flies and others.Many products containing spinosad are used on crops and ornamental plants. The active ingredient in Entrust SC Naturalyte is spinosad. Spinosad is an outstanding pesticide used in agriculture to control over pest and for increase the production. Brand names: NatrobaDrug class(es): topical anti-infectivesSpinosad topical is used in the treatment of: → Search the entire Drugs.com site for spinosad. Tradename (spinosad) Suspension, 0.9% was demonstrated to be statistically superior to an active comparator NIX (permethrin 1%) in each of two well-controlled pivotal, Phase 3 trials. The results table presents information on an active substance, such as approval start and end date, evaluating competent authority and approval or assessment status. Spinosad is also commonly used to kill thrips. It is a mixture of two chemicals called spinosyn A and spinosyn D. It is used to control a wide variety of pests. [6] The spinosyns and spinosoids have a novel mode of action, primarily targeting binding sites on nicotinic acetylcholine receptors (nAChRs) of the insect nervous system that are distinct from those at which other insecticides have their activity. There are two patents protecting this drug. Uses. [7] The apparent lack of spinosyn A metabolism may contribute to its high level of activity, and may compensate for the slow rate of penetration. Abamectin, Avid as it is often referred to in the generic, is an insecticide, acaricide and nematicide most commonly used by gardeners and the agriculture industry to fight off mites. Natroba is sold for treatment of human head lice. Min.Order: 1 Kilogram FOB Price: USD $ 1.0-3.0/Kilogram hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm This product is available in EC(Emulsifiable Concentrate),SC(Suspension Concentrate) form. Substance name: Spinosad. Information about pesticides used in urban situations. Seduce OG (spinosad): An insecticidal bait derived from the soil bacterium Saccharopolyspora spinosa; acts as a nerve and stomach poison. Your search for: "Spinosad" "Gf-120 nf naturalyte fruit fly bait" has produced 18 results. spinosad topical. IUPAC name: Spinosad as a mixture of 50-95 % spinosyn A and 5-50 % spinosyn D. EC number:-; 434-300-1 . It affects certain species only in the adult stage, but can affect other species at more than one life stage. [1] This genus is defined as aerobic, Gram-positive, nonacid-fast actinomycetes with fragmenting substrate mycelium. supplier Spinosad 168316-95-8. 2 Spinosad is an aerobic fermentation product of the soil bacterium, ... 32 Chemical Names: The name spinosad is derived from 33 combining the characters from spinosyn A and spinosyn 34 D. The material is a mixture of about 85% Spinosyn A ... 51 Trade Names: Tracer, Success, Conserve, Spintor. Suspension, External: Natroba: 0.9% (120 mL) [contains benzyl alcohol, cetearyl alcohol, fd&c yellow #6 (sunset yellow), isopropyl alcohol, propylene glycol] Generic: 0.9% (120 mL) [5] It is regarded as natural product-based, and approved for use in organic agriculture by numerous national and international certifications. nov. Isolated from soil Collected in a Sugar Mill Rum Still", 10.1002/1526-4998(200102)57:2<177::AID-PS281>3.0.CO;2-Z, "Spinosad: A new natural product for stored grain protection", "Resistance and cross-resistance to the spinosyns- A review and analysis", "Safer Flea Control | Insects in the City", "Codling Moth and Leafroller Control Using Chemicals", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in CD-1 Mice", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in Fischer 344 Rats", https://en.wikipedia.org/w/index.php?title=Spinosad&oldid=998542987, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Chemical articles with multiple PubChem CIDs, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Wikipedia articles needing clarification from June 2014, Creative Commons Attribution-ShareAlike License, This page was last edited on 5 January 2021, at 21:34. [2] It kills insects by hyperexcitation of the insect nervous system. [11][12][13], Spinosyn A does not appear to interact directly with known insecticidal-relevant target sites, but rather acts via a novel mechanism. Spinosyns occur in over 20 natural forms, and over 200 synthetic forms (spinosoids) have been produced in the lab. [7], Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. Common, Chemical and Trade Names of Insecticides Used in this Guide Trade Common Name Chemical Name IRAC Classification Company Abate Temephos O,O -(thiodi-4,1-phenylene) O,O, O' O'-tetramethyl phosphorothioate 1B BASF Corporation Abba Abamectin a mixture of avermectin B1a (10E,14E,16E,22Z)- [4] Spinosyn A is highly active against neonate larvae of the tobacco budworm, Heliothis virescens, and is slightly more biologically active than spinosyn D. In general, spinosyns possessing a methyl group at C6 (spinosyn D-related analogs) tend to be more active and less affected by changes in the rest of the molecule. Spinosad's widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remaining grain-importing countries. Known as a developmental or reproductive toxin in humans, this chemical is highly toxic to aquatic life. (g)/Ha Formulation Requirement / Ha Scope Triangle 1 Pryriproxifen 10% SC Lano Sumitomo Chem. Spinosad has recently been used in oral preparations (as Comfortis) to treat C. felis, the cat flea, in canines and felines; the optimal dose set for canines is reported to be 30 mg/kg. spinosad ( spy -no-sad) , Natroba (trade name) Classification Therapeutic: pediculocides Pregnancy Category: B Indications Treatment of head lice in adults and children >4 yr. Action Causes neuronal hyperexcitation in insects, resulting paralysis and death of lice. Spinosad, comprising spinosyn A and spinosyn D in a ratio of approximately 85:15, is the active ingredient in the formulations TRACER and LASER. It is marketed as the trade name Natroba in the US by ParaPRO Pharmaceuticals. Chemical formula: C83H132N2O20Drugbank ID: DB08823. Spinosad topical suspension, 0.9%, was approved by the U.S. Food and Drug Administration (FDA) on 2011-01-18 for the topical treatment of head lice infestation in patients four (4) years of age and older. Available for Android and iOS devices. However, these conditions led to decomposition of the 17-pseudoaglycone of … [7] Spinosyn A is slow to penetrate to the internal fluids of larvae; it is also poorly metabolized once it enters the insect. Spinosad has a unique mode of action that is different from all other known insect control products.It represents a new class of highly effective and safest insect control agent with superior and consistent control. 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